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Protein Science - Research Outputs - Lund University
These results indicate that Hsp21 represents an attractive alternative to Hsp90 for combinatorial immunotherapeutic-antifungal treatment strat-egies. Results Phylogenetic relatedness of C. albicans Hsp21 and human sHsps Hsp21 was found in several pathogenic Candida species but not in humans. This prompted us to investigate the effects of a broad range of different antifungal drugs on an Hsp21-null C. albicans mutant strain. Our results indicate that combinatorial therapy targeting Hsp21, together with specific antifungal drug targets, has strong synergistic Hsp21 was found in several pathogenic Candida species but not in humans. This prompted us to investigate the effects of a broad range of different antifungal drugs on an Hsp21-null C. HSP21: Small heat shock protein 21; Heat shock protein required for pathogenicity. Mediates thermotolerance and adaptation to oxidative stress and ethanol- induced stress.
Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans. Small heat shock proteins (sHsps) have multiple cellular functions. However, the biological function of sHsps in pathogenic microorganisms is largely unknown. Heat shock protein required for pathogenicity. Mediates thermotolerance and adaptation to oxidative stress and ethanol-induced stress. Required for invasive growth and filament formation under various filament inducing conditions.
In the present study we identified and characterized the novel sHsp Hsp21 of the human fungal pathogen Candida albicans.
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Candida albicans är en del av den normala mikrofloran i människans magtarmkanal och den finns i små mängder från munnen till och med tjocktarmen, och även i slidan. Hsp21 Potentiates Antifungal Drug Tolerance in Candida albicans Mayer, François L.; Mayer FL, Wilson D, Jacobsen ID, et al.
MASS SPEKTROMETRI - Avhandlingar.se
Small heat shock proteins (sHsps) have multiple cellular functions. However, the biological function of sHsps in pathogenic microorganisms is largely unknown. In the present study we identified and characterized the novel sHsp Hsp21 of the human fungal pathogen Candida albicans. Using a reverse genetics approach we demonstrate the importance of Hsp21 for resistance of C. albicans to specific unknown. One study of HSP21 from the pathogenic fungus Candida albicans indicates that sHSPs are directly involved in the adaption to specific stresses and are crucial for the pathogenicity of this fungus (Mayer et al., 2012).
We found that C. albicans biofilms were twofold more resistant to CAS with reference to planktonic
BibTeX @MISC{Albicans_smallbut, author = {Candida Albicans and François L. Mayer and Duncan Wilson and Ilse D. Jacobsen and Pedro Miramón and Silvia Slesiona and Iryna M. Bohovych and Alistair J. P. Brown and Bernhard Hube}, title = {Small but Crucial: The Novel Small Heat Shock Protein Hsp21 Mediates Stress Adaptation and Virulence in}, year = {}}
2020-10-01 · Multiple sequence alignment of the Pc-Hsp21 protein from Procambarus clarkii with other Hsp21 proteins.
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Hsp21 is also found in other fungal pathogens such as Candida Dissection of the Candida albicans lipase gene family and its role in Hube B ( 2013) Hsp21 potentiates antifungal drug tolerance in Candida albicans.
However, the biological function of sHsps in pathogenic microorganisms is largely unknown. In the present study we identified and characterized the novel sHsp Hsp21 of the human fungal pathogen Candida albicans. Using a reverse genetics approach we demonstrate the importance of Hsp21 for resistance of C. albicans to specific
unknown. One study of HSP21 from the pathogenic fungus Candida albicans indicates that sHSPs are directly involved in the adaption to specific stresses and are crucial for the pathogenicity of this fungus (Mayer et al., 2012).
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PLoS One, 8(3). Small heat shock proteins (sHsps) have multiple cellular functions. However, the biological function of sHsps in pathogenic microorganisms is largely unknown. In the present study we identified and characterized the novel sHsp Hsp21 of the human fungal pathogen Candida albicans.
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SWISS-MODEL Repository entry for Q5AHH4 (HSP21_CANAL), Small heat shock protein 21. Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Show simple item record. Small but crucial : the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans 2015-11-30 François L. Mayer's 20 research works with 1,097 citations and 3,955 reads, including: Candida albicans Mrv8, is involved in epithelial damage and biofilm formation Pedro Miramón's 38 research works with 650 citations and 2,048 reads, including: The Paralogous Transcription Factors Stp1 and Stp2 of Candida albicans Have Distinct Functions in Nutrient Hsp21 was found in several pathogenic Candida species but not in humans. This prompted us to investigate the effects of a broad range of different antifungal drugs on an Hsp21-null C. albicans mutant strain.